| Admixture
Breast Cancer & Breast Density Among Latinas
Funding
Provided By: National Cancer Institute
Principal
Investigator: Elad Ziv, MD, Assistant Professor of Medicine
and Epidemiology and Biostatistics, University of California
at San Francisco
The study
involves an analysis of the association of genetic variations
(polymorphisms) with breast density. We plan to enroll women
who have previously participated in the San Francisco Mammography
Registry and who have had breast density measurements recorded
in the registry. We will invite women based on their breast
density measurements, targeting two groups of women: those with
the lowest and highest breast density. We will then analyze
a series of genetic markers to determine whether these are associated
with higher breast density. We plan to focus on Latina women
in this study because of the demographic history of Latinas
as an “admixed” population (i.e. they have ancestry
from several groups including Europeans, Native Americans and
Africans). Admixed populations may be particularly helpful in
identifying genetic variations associated with complex diseases
by an approach called “admixture mapping.”
Markers
of Breast Density That Predict Cancer
Funding
Provided By: National Cancer Institute
Principal
Investigator: Karla Kerlikowske, MD, Associate Professor of
Medicine and Epidemiology and Biostatistics, University of California
at San Francisco
There
is little understanding of what breast density represents at
the breast tissue level. This study will measure associations
with selected markers and breast density in a population-based
sample and investigate whether those markers associated with
increased breast density also predict breast cancer. We will
also examine the association between polymorphisms and haplotypes
in a well-characterized gene, TGF-?1, with extent of breast
density.
Breast
Cancer Prevention: The Views of Women and Physicians
Funding
Provided By: California Breast Cancer Research Program, University
of California
Principal
Investigator: Celia Patricia Kaplan, DrPH, Associate Adjunct
Professor of Medicine, University of California at San Francisco
This study
examined the knowledge, attitudes, and practices of women and
physicians with regard to breast cancer prevention. The investigators
conducted a telephone survey of 1,700 women from four ethnic
groups who were at varying risk of breast cancer. Participants
were recruited from the San Francisco Mammography Registry (SFMR).
Women were eligible for the study if they were between 40 and
75 years of age, had no prior history of breast cancer, and
spoke English, Spanish, or Cantonese. The survey examined women's
perceived risk for breast cancer and knowledge of risk assessment
tools and available options for the primary prevention of breast
cancer. The investigators also surveyed 822 randomly selected
physicians from 3 different specialties (general internal medicine,
family medicine, and obstetrics/gynecology) practicing in California.
This survey examined physician knowledge of breast cancer prevention
and beliefs about the effectiveness of current therapies. Physicians'
current practices, attitudes, and the perceived obstacles related
to breast cancer prevention were also examined. This information
was used to determine differences among physicians based on
the type of practice, gender, or the geographic location of
their medical practice.
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Compositional Breast Density as a Risk Factor
Funding
Provided By: California Breast Cancer Research Program, University
of California at San Francisco (UCSF)
Principal
Investigators: John Shepherd, PhD, Assistant Professor, Department
of Radiology, UCSF; Karla Kerlikowske, MD, Department of Medicine
and Epidemiology and Biostatistics, UCSF; Steve Cummings, MD,
Department of Medicine and Epidemiology and Biostatistics, UCSF
This study
will examine whether single x-ray absorptiometry (SXA) and compositional
densitometry (DXA) are more accurate and precise measures of
breast cancer risk than is the BI-RADS® categorical system
among 25 women with breast cancer and 25 matched controls without
breast cancer. Women without breast cancer are identified as
potential participants through the San Francisco Mammography
Registry based on postmenopausal status, current hormone therapy
use, and whether they have a history of breast cancer.
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Soy for Breast Cancer Prevention in High-risk Premenopausal
Women
Funding
Provided By: U.S. Department of Defense
Principal
Investigator: Jeff Tice, MD, Assistant Adjunct Professor, Department
of Medicine, UCSF
This
study is a randomized controlled trial to determine the effect
of soy on breast tissue density. Women are identified as potential
participants through the San Francisco Mammography Registry
according to their menopausal status, mammographic breast density,
and Gail breast cancer risk assessment score.
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Racial
Disparity in Breast Cancer Mortality
Funding Provided By: California Breast Cancer Research
Program, University of California
Principal Investigators: Rebecca Smith-Bindman, MD, Associate
Professor, Departments of Radiology and Epidemiology and Biostatistics,
UCSF
The goal of this project is to understand the etiology of the
racial differences in breast cancer mortality by comparing the
stage of disease at diagnosis in a population of women where
the use (and frequency) of screening mammography is known. In
this study we are using data from the NCI Breast Cancer Surveillance
Consortium and SEER Medicare data |
